系别：化学系

职称：河南大学“杰出人才特区支持计划”第四层次特聘教授

邮箱：zycao@henu.edu.cn

个人简介：

曹中艳，男，玛丽·居里协会会员，1988年出生于安徽亳州，任职于河南大学化学化工学院，特聘教授。已发表第一作者和通讯作者SCI论文17篇（含共同一作四篇），包括自然子刊Nature Commun.1篇，J. Am. Chem. Soc.1篇，Acc. Chem. Res.1篇，Angew. Chem., Int. Ed.1篇；其中14篇为JCR一区，14篇论文影响因子大于5；以第二作者在Chem. Rev., J. Am. Chem. Soc.和Angew. Chem. Int. Ed.等顶级期刊发表SCI论文7篇；共发表SCI论文40余篇，论文他引约2000次，有4篇论文入选ESI高被引用论文，1篇为热点论文；以第一、二作者身份撰写英文专著各两章，以及中文专著一节，共计四万余字；授权中国发明专利两项。曾获得国家研究生奖学金、宝钢奖学金、华师大学术新人奖、入选优博培育计划，以及欧盟玛丽·居里奖学金等。

主要教育经历：

2010年9月-2015年11月，华东师范大学，化学化工学院，直博，理学博士 (导师：周剑教授)

2006年9月-2010年7月，华东师范大学，化学化工学院，理学学士（本科毕设导师：麻生明教授，刘宇博士）

主要研究工作经历：

2020年11月至今，河南大学，化学化工学院，硕士生导师，河南大学“杰出人才特区支持计划”第四层次特聘教授

2019年8月-2020年11月，浙江工业大学，化学工程学院

2018年12月-2019年8月，新加坡南洋理工大学，博士后，合作导师：周建荣教授

2016年5月-2018年8月，西班牙ICIQ研究所，博士后，合作导师：Paolo Melchiorre教授

主要研究方向：

不对称催化，光、电催化，自由基化学，绿色高分子材料合成

承担基金：

河南大学“杰出人才特区支持计划”第四层次科研启动基金，2020-2025

欧盟玛丽·居里基金，2016-2018

学术兼职：

中国化学会会员、玛丽居里协会会员、Frontiers in Chemistry、RSC Advances和Frontiers in Catalysis杂志青年编委

部分同行评议论文 (他引次数约 2000; H指数 = 20)

1.        (1-Selenocyanatoethyl)benzene: A Selenocyanation Reagent for Site-Selective Selenocyanation of Inert Alkyl C(sp3)−H Bonds

Fei Yu, Chuang Li, Chuangye Wang, Hongwei Zhang,* and Zhong-Yan Cao*, Org. Lett., 2021, DOI: 10.1021/acs.orglett.1c02564

2.        Catalytic Asymmetric Synthesis of Monofluoroalkenes and gem-Difluoroalkenes: Advances and Perspectives

X. Zhang, Y. Cheng, X. Zhao, Z.-Y. Cao*, X. Xiao*, Y. Xu*, Org. Chem. Front. 2021, 8, 2315.  (IF = 5.15)

3.        Copper-Catalyzed Remote Direct Thiocyanation of Alkyl C(sp3)–H Bonds

Q. Wang, P. Tian, Z.-Y. Cao*, H. Zhang*, C. Jiang, Adv. Synth. Catal. 2020, 362, 3851. (IF = 5.86)

4.        Activating pronucleophiles with high pKa values: Chiral organo-superbases.

Y.-H. Wang‡, Z.-Y. Cao‡, Q.-H. Li, G.-Q. Lin, J. Zhou*, P. Tian* Angew. Chem., Int. Ed. 2020, 59, 8004.       

 (IF = 12.96)       (‡co-first authors)

5.        Enantioselective radical conjugate additions driven by the photoactivity of an intramolecular iminium-ion-based EDA complex.

Z.-Y. Cao, T. Ghosh, P. Melchiorre*, Nature Commun. 2018, 9 (3274), DOI: 10.1038/s41467-018-05375-2.  (IF = 12.12)

6.        Development of synthetic methodologies via catalytic enantioselective synthesis of 3,3-disubstituted oxindoles.

Z.-Y. Cao, F. Zhou, J. Zhou*, Acc. Chem. Res., 2018, 51, 1443.  (IF = 20.83)    (ESI高被引用论文，热点论文)

7.        Highly stereoselective olefin cyclopropanation of diazooxindoles catalyzed by a C2-symmetric spiroketal bisphosphine/Au(I) complex.                                      (ESI高被引用论文)

Z.-Y. Cao, X. Wang, C. Tan, X.-L. Zhao, J. Zhou*, K. Ding, J. Am. Chem. Soc. 2013‚ 135‚ 8197.         (IF = 14.61)

8.        Catalytic enantioselective synthesis of cyclopropanes featuring vicinal all-carbon quaternary stereocenters with a CH2F group; study of the influence of C–F⋯H–N interactions on reactivity.                    (‡co-first authors)

Z.-Y. Cao‡, W. Wang‡, K. Liao, X. Wang, J. Zhou*, J. Ma*, Org. Chem. Front. 2018, 5, 2960.          (IF = 5.16)

9.        Sequential Au(I)/chiral tertiary amine catalysis: a tandem C–H functionalization of anisoles or a thiophene/asymmetric Michael addition sequence to quaternary oxindoles.                                  (‡co-first authors)

Z.-Y. Cao‡, Y.-L. Zhao‡, J. Zhou*, Comm. Commun. 2016, 52, 2537. (IF = 6.00)

10.      Asymmetric sequential Au(I)/chiral tertiary amine catalysis: an enone-formation/cyanosilylation sequence to synthesize optically active 3-alkenyloxindoles from diazooxindoles.                             (‡co-first authors) 

Y.-L. Zhao‡, Z.-Y. Cao‡, X.-P. Zeng, J.-M. Shi, Y.-H. Yu, J. Zhou*, Comm. Commun. 2016, 52, 3943. (IF = 6.00)

11.      A highly diastereo- and enantioselective Hg(II)-catalyzed cyclopropanation of diazooxindoles and alkenes

Z.-Y. Cao, F. Zhou, Y.-H. Yu, J. Zhou*, Org. Lett. 2013‚ 15, 42.        (Highlighted by Synfacts 2013‚ 415.) (IF = 6.09)

12.      A Hg(ClO4)2•3H2O catalyzed Sakurai-Hosomi allylation of isatins and isatin ketoimines using allyltrimethylsilane.

Z.-Y. Cao‚ Y. Zhang‚ C.-B. Ji‚ J. Zhou*‚ Org. Lett. 2011‚ 13‚ 6398.             (IF = 6.09)

13.      A highly enantioselective Hg(II)-catalyzed Sakurai–Hosomi reaction of isatins with allyltrimethylsilanes.

Z.-Y. Cao, J.-S. Jiang, J. Zhou*, Org. Biomol. Chem. 2016, 14, 5500. (Invited paper for New Talent Issue) (IF = 3.41)

14.      Catalytic asymmetric synthesis of 3,3-disubstituted oxindoles: diazooxindole joins the field.

Z.-Y. Cao, Y.-H. Wang, X.-P. Zeng, J. Zhou*, Tetrahedron Lett. 2014, 55, 2571. (Invited Digest Paper) (IF = 2.28)

15.      Recent advances in the use of chiral metal complexes with achiral ligands for application in asymmetric catalysis.

Z.-Y. Cao, W. D. G. Brittain, J. S. Fossey, F. Zhou*, Catal. Sci. Technol. 2015, 5, 3341.  (Cover Paper) (IF = 5.72)

16.      Catalytic asymmetric synthesis of spirocyclopropyl oxindoles: organocatalysis versus transition metal catalysis.

Z.-Y. Cao, J. Zhou*, Org. Chem. Front. 2015, 2, 849.                         (IF = 5.16)

17.      Carbon tetrabromide. 

Z.-Y. Cao, Synlett, 2013, 24, 889.                               (IF = 2.00)

18.      Highly stereoselective Gold-catalyzed coupling of diazo reagents and fluorinated enol silyl ethers to tetrasubstituted alkenes

F.-M. Liao, Z.-Y. Cao, J.-S. Yu, J. Zhou*, Angew. Chem., Int. Ed. 2017, 56, 2459.                    (IF = 12.96)

19.      Catalytic enantioselective desymmetrization reactions to all-carbon quaternary stereocenters.  (ESI高被引用论文)

X.-P. Zeng, Z.-Y. Cao, Y.-H. Wang, F. Zhou, J. Zhou*, Chem. Rev. 2016, 116, 7330.           (IF = 52.76) 

20.      Activation of chiral (Salen)AlCl complex by phosphorane for highly enantioselective cyanosilylation of ketones and enones

X.-P. Zeng, Z.-Y. Cao, X. Wang, L. Chen, F. Zhou, F. Zhu, C.-H. Wang, J. Zhou*, J. Am. Chem. Soc. 2016‚ 138‚ 416.

(IF = 14.61)

21.  Catalytic Enantioselective Construction of Spiro Quaternary Carbon Stereocenters.         (ESI高被引用论文)

P.-W. Xu, J.-S. Yu, C. Chen, Z.-Y. Cao, F. Zhou, J. Zhou*, ACS Catal. 2019, 9, 1820.  (IF = 12.35)

22.  Diastereo- and enantioselective [3+3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones. P.-W. Xu, J.-K. Liu, L. Shen, Z.-Y. Cao, X.-L. Zhao, J. Yan*, J. Zhou*

Nature Commun. 2017, 8 (1619), DOI: 10.1038/s41467-017-01451-1.  (IF = 12.12)

23.  Nucleophilic difluoromethylenation of ketones using diethyl (difluoro(trimethylsilyl)methyl)phosphonate mediated by 18-Crown-6 ether/KOAc.

Y.-H. Wang, Z.-Y. Cao, J. Zhou*, J. Org. Chem. 2016, 81, 7807.               (IF = 4.34) 

24.  A catalyst-free, one-pot three-component aminomethylation of alpha-substituted nitroacetates: theoretical and experimental studies into the rate-accelerating effects of the solvent methanol.

C.-B. Ji, Z.-Y. Cao, X. Wang,* D.-Y. Wu, J. Zhou*, Chem. Asian J. 2013, 8, 877.  (IF = 4.06)  

25.      A highly efficient Friedel-Crafts reaction of 3-hydroxyoxindoles and aromatic compounds to 3,3-diaryl and 3-alkyl-3-aryloxindoles catalyzed by Hg(ClO4)2•3H2O.

F. Zhou‚ Z.-Y. Cao‚ J. Zhang‚ H. B. Yang‚ J. Zhou*‚ Chem. Asian J. 2012‚ 7‚ 233.  (IF = 4.06)     

26.      Hydroxymethylation of α-substituted nitroacetates.

C.-B. Ji‚ Y.-L. Liu‚ Z.-Y. Cao‚ Y.-Y. Zhang‚ J. Zhou*, Tetrahedron Lett. 2011‚ 52‚ 6118.        (IF = 2.28) 

学术专著 (四章英文专著和一节中文专著)

27.      Z.-Y. Cao, F. Zhu, J. Zhou*, Chapter 2, P37-158; L. Chen, Z.-Y. Cao, J. Zhou*, Chapter 5, P373-410; Z.-Y. Cao, J. Zhou*, Chapter 7, P475-500, “Multicatalyst System in Asymmetric Catalysis”, John Wiley & Sons Inc., New York, 2014.

28.      周剑、曹中艳，丁奎岭手性螺缩酮双膦配体(SKP), p748, 黄培强主编，有机人名反应、试剂与规则，第二版，化学工业出版社，2019.

29.      Y.-H. Wang, Z.-Y. Cao, J. Zhou*, “Gold Catalysis in the Synthesis of Natural Products: Heterocycle Construction via Direct C-X-Bond-Forming Reactions”, P1-35, Au-Catalyzed Synthesis and Functionalization of Heterocycles, Springer Berlin Heidelberg, 2016.

授权专利

30.      周剑, 曹中艳 中国发明专利, ZL201110024744.3 2012.

31.      周剑，周锋，刘亮，曹中艳 中国发明专利，ZL201110022559.0 2011.