姓名：李冠亚

职称：讲师

籍贯：河南周口

电子邮箱：gyl@henu.edu.cn

教育及工作经历：

2012.09-2016.06 河南科技大学 本科

2016.09-2019.06 湖南农业大学 硕士

2016.09-2019.06 中国科学院亚热带农业生态研究所（联合培养）

2019.09-2024.06 湖南师范大学 博士

2024.12-至今    河南大学 讲师

研究方向：（1）EBV与宿主代谢重编程相关研究；（2）基于LNP的纳米药物靶向递送治疗淋巴瘤相关研究；（3）疱疹病毒致瘤机制相关研究及靶点筛查及鉴定。

代表性成果：

1.      Xinyu Tang^#, Guanya Li^#,*, Ru Li, Yinan Li, Lijie Wang, Zeyu Xu, Enguo Ju, Jian Shang,Shanping He^*, Tingting Li^*. A viral Cyclin D homolog protein inhibits SESN2 ubiquitinationand degradadation. PNAS, 2025.

2.      Guanya Li^#, Yinan Li^#, Xinyu Tang, Lijie Wang, Enguo Ju, Shanping He, Tingting Li.LKB1-AMPK pathway promotes primary effusion lymphoma progression by suppressing KSHVreactivation. J Virol. 2024.

3.      Guanya Li^#, Kai Xiao^#, Yinan Li, Jianfang Gao, Shanping He, Tingting Li. CHIPpromotes CAD ubiquitination and degradation to suppress the proliferation and colonyformation of glioblastoma cells. Cell oncol. 2023.

4.      Shusheng Yue^#, Guanya Li^#, Shanping He and Tingting Li. The central role of mTORC1in amino acid sensing. Cancer Res. 2022

5.      Guanya Li, Dunhui Li, Tao Wang and Shanping He. Pyrimidine Biosynthetic Enzyme CAD:Its Function, Regulation, and Diagnostic Potential. Int J Mol Sci. 2021

6.      Guanya Li, Zhenglin Dong, Shusheng Yue, Dan Wan, Yulong Yin. Paternal Zn-deficiencyabolishes metabolic effects in offspring induced by diet type. Anim Nutr. 2021

7.      Guanya Li, Qinhua Wang, Dan Wan, Chunyan Xie, Xin Wu, Yulong Yin. Uridine/UMP metabolism andtheir function on gut of infant in a segregated early-weaned piglet model. Food & Funct. 2019

8.      Guanya Li, Guanglei Zhang, Dan Wan, Chunyan Xie, Hong Wang, Zhiyong Fan. Effects of oraladministration of dbcAMP-Ca on growth performance and lipid fatty acids metabolism in weaning piglets. Anim Nutr. 2018