范文辉
邮箱：fanwenhui78@aliyun.com
教育及工作经历：
1998.09—2002.07，河南师范大学，学士
2002.09—2005.07，中国海洋大学，硕士
2011.09—2015.03，广西大学，博士
2009.01-2024.09，中国科学院微生物研究所，副研究员
2024.10—至今：河南大学，化学与分子科学学院，副研究员
研究方向：
抗病毒药物、疫苗及佐剂
论文成果：
1、Bingxin Wang , Yingyan Chang， Lulu Shen , Yunmeng Ma , Zhikang Zhang , Jiahao Du , Yu Wang , Yuanyuan Li , Fenqin Zhao , Junfeng Wang , Xiaobin Pang Wenhui Fan* , Lida Du *, Lin Yan* ，Multifunctional near-infrared fluorescent probe for imaging of hydrogen peroxide and photodynamic therapy of amyloid-β aggregation in Alzheimer’s disease，Talanta，2026 Feb 1;298
2、Huizi Li, Wenhui Fan*, Jie Min, Xiaoyuan Bai, Wenxian Yang, Heqiao Li, Yuna Zhao, Runshan Lin, Xiaojuan Jia, Wenjun Liu*, Lei Sun *. Cyclophilin A facilitates influenza B virus replication by stabilizing viral proteins, iScience, 2023 Nov 7
3、Pengtao Jiao#, Shuchao Wang#, Wenhui Fan #, He Zhang , Hongyan Yin, Yingli Shang, Hongfei Zhu, Wenjun Liu, Rongliang Hu, Lei Sun. Recombinant porcine interferon cocktail delays the onset and lessens the severity of African swine fever. Antiviral Research. 2023 Jul;215:105644.
4、Wenhui Fan, Shanshan Sun , Ning Zhang, Yuan Zhang , Pengtao Jiao , Jian Wang, George F Gao, Wenjun Liu, Yuhai Bi , Limin Yang*. Nasal delivery of thermostable and broadly neutralizing antibodies protects mice against SARS-CoV-2 infection. Signal Transduction and Targeted Therapy 2022 Feb 21;7(1):55
5、Wenhui Fan, Ying Cao, Pengtao Jiao, Ping Yu , He Zhang, Teng Chen, Xintao Zhou, Yu Qi, Lei Sun, Di Liu , Hongfei Zhu , Wenjun Liu, Rongliang Hu, Jing Li. Synergistic effect of the responses of different tissues against African swine fever virus. Transboundary and Emerging Diseases. 2022 Jul; 69(4): e204–e215
6、Wenqiang Sun，He Zhang，Xiaodong Tian，Lihong He，Zhihua Bai，Limin Yang，Xiaojuan Jia，Yuhai Bi，Tingrong Luo，Gong Cheng，Wenhui Fan*，Wenjun Liu*，Jing Li*. The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice. Signal Transduction and Targeted Therapy (2021)6:340.
7、Xuguang Du#, Zihang Guo#, Wenhui Fan#, Tang Hai#, Fei Gao, Pan Li, Yumin Qin, Chaolei Chen, Zhiqiang Han, Jilong Ren, Pengtao Jiao, Wenjun Liu, Yuhai Bi, Dawei Yu, Sen Wu，Establishment of a Humanized Swine Model for COVID-19 Cell Discovery (2021)7:70.
8、Wenhui Fan, Pengtao Jiao, He Zhang, Teng Chen, Xintao Zhou, Yu Qi, Lei Sun, Yingli Shang, Hongfei Zhu, Rongliang Hu, Wenjun Liu， Jing Li*. Inhibition of African Swine Fever Virus Replication by Porcine Type I and Type II Interferons, Frontiers in Microbiology, 04 June 2020
主持项目：
1. 国家自然科学基金委员会, 面上项目, 32070164, 亲环素A调控B型流感病毒复制的机制, 2021-01-01 至 2024-12-31, 58万元, 主持
2. 中华人民共和国科学技术部, 国家重点研发计划, 2021YFD1801200, 非洲猪瘟基因缺失疫苗研发, 2021-12 至 2024-11, 300万元, 子课题主持
3. 中华人民共和国国家卫生健康委员会, 国家科技重大专项, 2018ZX10101004, 东非、中亚和东南亚等 区域重要传染病防控关键保障技术研究, 2018-01 至 2020-12, 88万元,子课题主持
4. 消毒剂样品对SARS-CoV-2杀灭效率研究，横向技术开发项目，2020-12-01至2021-11-30，110万元，主持
5. 非洲猪瘟病毒疫苗技术开发，横向技术开发项目，2019110008001515，2019-06-04至2024-06-03，80万美元，共同主持
